244147

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4170080..4171122 Replicon chromosome
Accession NZ_CP096909
Organism Pseudomonas aeruginosa strain NY8688

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag M2J77_RS19445 Protein ID WP_003109777.1
Coordinates 4170080..4170655 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag M2J77_RS19450 Protein ID WP_003050245.1
Coordinates 4170652..4171122 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J77_RS19420 (M2J77_19375) 4166518..4167243 - 726 WP_003050273.1 CBASS effector endonuclease NucC -
M2J77_RS19425 (M2J77_19380) 4167282..4168184 - 903 WP_003105624.1 CBASS oligonucleotide cyclase -
M2J77_RS19430 (M2J77_19385) 4168184..4168684 - 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
M2J77_RS19435 (M2J77_19390) 4168681..4169151 - 471 WP_003105626.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
M2J77_RS19440 (M2J77_19395) 4169148..4170062 - 915 WP_003105629.1 AAA family ATPase -
M2J77_RS19445 (M2J77_19400) 4170080..4170655 - 576 WP_003109777.1 PIN domain-containing protein Toxin
M2J77_RS19450 (M2J77_19405) 4170652..4171122 - 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
M2J77_RS19455 (M2J77_19410) 4171326..4171709 + 384 WP_003120001.1 RAQPRD family integrative conjugative element protein -
M2J77_RS19460 (M2J77_19415) 4171706..4171939 + 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
M2J77_RS19465 (M2J77_19420) 4171956..4172315 + 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
M2J77_RS19470 (M2J77_19425) 4172327..4172725 + 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
M2J77_RS19475 (M2J77_19430) 4172722..4173414 + 693 WP_003105641.1 TIGR03746 family integrating conjugative element protein -
M2J77_RS19480 (M2J77_19435) 4173411..4174322 + 912 WP_003105643.1 TIGR03749 family integrating conjugative element protein -
M2J77_RS19485 (M2J77_19440) 4174312..4175730 + 1419 WP_020924934.1 TIGR03752 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4120549..4221515 100966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21644.79 Da        Isoelectric Point: 5.6172

>T244147 WP_003109777.1 NZ_CP096909:c4170655-4170080 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT244147 WP_003050245.1 NZ_CP096909:c4171122-4170652 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References