Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3130362..3131583 Replicon chromosome
Accession NZ_CP096909
Organism Pseudomonas aeruginosa strain NY8688

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M2J77_RS14825 Protein ID WP_003114949.1
Coordinates 3130362..3130940 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M2J77_RS14830 Protein ID WP_003088112.1
Coordinates 3131029..3131583 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J77_RS14810 (M2J77_14790) 3125639..3126916 + 1278 WP_003122808.1 TolC family protein -
M2J77_RS14815 (M2J77_14795) 3126906..3129077 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
M2J77_RS14820 (M2J77_14800) 3129067..3130254 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
M2J77_RS14825 (M2J77_14805) 3130362..3130940 - 579 WP_003114949.1 HD domain-containing protein Toxin
M2J77_RS14830 (M2J77_14810) 3131029..3131583 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M2J77_RS14835 (M2J77_14815) 3131741..3133936 - 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M2J77_RS14840 (M2J77_14820) 3133941..3134402 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
M2J77_RS14845 (M2J77_14825) 3134733..3135056 + 324 WP_003102734.1 multidrug efflux SMR transporter -
M2J77_RS14850 (M2J77_14830) 3135069..3135467 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M2J77_RS14855 (M2J77_14835) 3135464..3136015 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T244146 WP_003114949.1 NZ_CP096909:c3130940-3130362 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT244146 WP_003088112.1 NZ_CP096909:c3131583-3131029 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References