244144

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 1840398..1841006 Replicon chromosome
Accession NZ_CP096909
Organism Pseudomonas aeruginosa strain NY8688

Toxin (Protein)


Gene name PfiT Uniprot ID A0A3S4N9Q9
Locus tag M2J77_RS08535 Protein ID WP_031672658.1
Coordinates 1840659..1841006 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag M2J77_RS08530 Protein ID WP_003114155.1
Coordinates 1840398..1840649 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J77_RS08510 (M2J77_08505) 1836036..1836386 + 351 WP_003159569.1 DUF2523 family protein -
M2J77_RS08515 (M2J77_08510) 1836388..1837650 + 1263 WP_049290957.1 zonular occludens toxin domain-containing protein -
M2J77_RS08520 (M2J77_08515) 1837909..1839201 + 1293 WP_071659043.1 hypothetical protein -
M2J77_RS08525 (M2J77_08520) 1839201..1840184 + 984 WP_031672657.1 tyrosine-type recombinase/integrase -
M2J77_RS08530 (M2J77_08525) 1840398..1840649 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M2J77_RS08535 (M2J77_08530) 1840659..1841006 + 348 WP_031672658.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2J77_RS08545 (M2J77_08540) 1841333..1842235 - 903 WP_003123042.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
M2J77_RS08550 (M2J77_08545) 1842686..1843423 - 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
M2J77_RS08555 (M2J77_08550) 1843503..1844546 - 1044 WP_003098363.1 L,D-transpeptidase -
M2J77_RS08560 (M2J77_08555) 1844682..1845374 - 693 WP_003098362.1 16S rRNA pseudouridine(516) synthase -
M2J77_RS08565 (M2J77_08560) 1845374..1845646 - 273 WP_003120794.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1827848..1841156 13308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12898.69 Da        Isoelectric Point: 4.5143

>T244144 WP_031672658.1 NZ_CP096909:1840659-1841006 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGAQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT244144 WP_003114155.1 NZ_CP096909:1840398-1840649 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S4N9Q9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References