Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4686683..4687311 Replicon chromosome
Accession NZ_CP096905
Organism Citrobacter amalonaticus strain RSHH22

Toxin (Protein)


Gene name vapC Uniprot ID A0A7L6UNG2
Locus tag M2R49_RS22510 Protein ID WP_044328134.1
Coordinates 4686683..4687069 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M2R49_RS22515 Protein ID WP_161215612.1
Coordinates 4687069..4687311 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2R49_RS22490 (M2R49_22470) 4682036..4683373 + 1338 WP_086512772.1 VWA domain-containing protein -
M2R49_RS22495 (M2R49_22475) 4683391..4684887 + 1497 WP_044265164.1 HAMP domain-containing sensor histidine kinase -
M2R49_RS22500 (M2R49_22480) 4684892..4685578 + 687 WP_054177415.1 response regulator transcription factor -
M2R49_RS22505 (M2R49_22485) 4685723..4686652 + 930 WP_054177416.1 formate dehydrogenase accessory protein FdhE -
M2R49_RS22510 (M2R49_22490) 4686683..4687069 - 387 WP_044328134.1 type II toxin-antitoxin system VapC family toxin Toxin
M2R49_RS22515 (M2R49_22495) 4687069..4687311 - 243 WP_161215612.1 CopG family transcriptional regulator Antitoxin
M2R49_RS22520 (M2R49_22500) 4687519..4688445 + 927 WP_054177417.1 alpha/beta hydrolase -
M2R49_RS22525 (M2R49_22505) 4688461..4689402 - 942 WP_042998862.1 fatty acid biosynthesis protein FabY -
M2R49_RS22530 (M2R49_22510) 4689447..4689884 - 438 WP_044265155.1 D-aminoacyl-tRNA deacylase -
M2R49_RS22535 (M2R49_22515) 4689881..4690753 - 873 WP_044257165.1 virulence factor BrkB family protein -
M2R49_RS22540 (M2R49_22520) 4690747..4691346 - 600 WP_044265152.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14394.61 Da        Isoelectric Point: 8.4794

>T244141 WP_044328134.1 NZ_CP096905:c4687069-4686683 [Citrobacter amalonaticus]
MQKGPVLFDTNILIDLFSGHQEAQHVLEAYPPQNAISLVTWMEVMVGAKKYHQEYRTRVALSAFNIIGVSQEIAERSVNL
RQEYGMKLPDAIILATAQIHRFALVTRNTRDFAGIPGVITPYQLQAGR

Download         Length: 387 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9335.53 Da        Isoelectric Point: 4.2075

>AT244141 WP_161215612.1 NZ_CP096905:c4687311-4687069 [Citrobacter amalonaticus]
IMAGMDMGRILLDLSDEVIKRLDDLKQQRNLPRAELLREAVEQYLERQGQAETTISNALGLWQGCEEDGVEYQRTLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6UNG2

Antitoxin

Source ID Structure

References