Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3997794..3998448 Replicon chromosome
Accession NZ_CP096905
Organism Citrobacter amalonaticus strain RSHH22

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Q8D714
Locus tag M2R49_RS19320 Protein ID WP_044254016.1
Coordinates 3997794..3998201 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F6TWP9
Locus tag M2R49_RS19325 Protein ID WP_042322123.1
Coordinates 3998182..3998448 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2R49_RS19300 (M2R49_19285) 3993699..3995432 - 1734 WP_042999369.1 single-stranded-DNA-specific exonuclease RecJ -
M2R49_RS19305 (M2R49_19290) 3995438..3996151 - 714 WP_054176762.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M2R49_RS19310 (M2R49_19295) 3996175..3997071 - 897 WP_042999367.1 site-specific tyrosine recombinase XerD -
M2R49_RS19315 (M2R49_19300) 3997172..3997693 + 522 WP_042999366.1 flavodoxin FldB -
M2R49_RS19320 (M2R49_19305) 3997794..3998201 - 408 WP_044254016.1 protein YgfX Toxin
M2R49_RS19325 (M2R49_19310) 3998182..3998448 - 267 WP_042322123.1 FAD assembly factor SdhE Antitoxin
M2R49_RS19330 (M2R49_19315) 3998705..3999685 + 981 WP_044254013.1 tRNA-modifying protein YgfZ -
M2R49_RS19335 (M2R49_19320) 3999766..4000425 - 660 WP_263504052.1 hemolysin III family protein -
M2R49_RS19340 (M2R49_19325) 4000588..4000899 - 312 WP_054176763.1 N(4)-acetylcytidine aminohydrolase -
M2R49_RS19345 (M2R49_19330) 4000952..4001680 + 729 WP_044254008.1 MurR/RpiR family transcriptional regulator -
M2R49_RS19350 (M2R49_19335) 4001800..4003233 + 1434 WP_054176764.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15863.86 Da        Isoelectric Point: 11.6030

>T244139 WP_044254016.1 NZ_CP096905:c3998201-3997794 [Citrobacter amalonaticus]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVSAPWMIKTGMMLRLRSETGKRQHLWLAADSMDKAEWRDLRRLMMQPSTQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.06 Da        Isoelectric Point: 5.1496

>AT244139 WP_042322123.1 NZ_CP096905:c3998448-3998182 [Citrobacter amalonaticus]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q8D714

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TWP9

References