Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1332507..1333127 Replicon chromosome
Accession NZ_CP096905
Organism Citrobacter amalonaticus strain RSHH22

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag M2R49_RS06335 Protein ID WP_001280991.1
Coordinates 1332507..1332725 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q8DH98
Locus tag M2R49_RS06340 Protein ID WP_042324455.1
Coordinates 1332753..1333127 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2R49_RS06305 (M2R49_06300) 1328160..1328756 + 597 WP_054176084.1 membrane protein -
M2R49_RS06310 (M2R49_06305) 1328839..1329192 + 354 WP_043001561.1 DUF1428 family protein -
M2R49_RS06315 (M2R49_06310) 1329232..1330782 - 1551 WP_054176085.1 EAL domain-containing protein -
M2R49_RS06320 (M2R49_06315) 1331005..1331145 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
M2R49_RS06325 (M2R49_06320) 1331195..1331665 - 471 WP_043001559.1 YlaC family protein -
M2R49_RS06330 (M2R49_06325) 1331779..1332330 - 552 WP_044258934.1 maltose O-acetyltransferase -
M2R49_RS06335 (M2R49_06330) 1332507..1332725 - 219 WP_001280991.1 HHA domain-containing protein Toxin
M2R49_RS06340 (M2R49_06335) 1332753..1333127 - 375 WP_042324455.1 Hha toxicity modulator TomB Antitoxin
M2R49_RS06345 (M2R49_06340) 1333639..1336788 - 3150 WP_043001557.1 efflux RND transporter permease AcrB -
M2R49_RS06350 (M2R49_06345) 1336811..1338004 - 1194 WP_043001556.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T244129 WP_001280991.1 NZ_CP096905:c1332725-1332507 [Citrobacter amalonaticus]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8989

>AT244129 WP_042324455.1 NZ_CP096905:c1333127-1332753 [Citrobacter amalonaticus]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q8DH98

References