Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1332507..1333127 Replicon chromosome
Accession NZ_CP096905
Organism Citrobacter amalonaticus strain RSHH22

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag M2R49_RS06335 Protein ID WP_001280991.1
Coordinates 1332507..1332725 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q8DH98
Locus tag M2R49_RS06340 Protein ID WP_042324455.1
Coordinates 1332753..1333127 (-) Length 125 a.a.

Genomic Context

M2R49_RS06305M2R49_RS06310M2R49_RS06320M2R49_RS06315M2R49_RS06325M2R49_RS06330M2R49_RS06335M2R49_RS06340M2R49_RS06345M2R49_RS06350
Location: 1328160..1328756 (597 bp)
Type: Others
Protein ID: WP_054176084.1
Location: 1328839..1329192 (354 bp)
Type: Others
Protein ID: WP_043001561.1
Location: 1331005..1331145 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 1329232..1330782 (1551 bp)
Type: Others
Protein ID: WP_054176085.1
Location: 1331195..1331665 (471 bp)
Type: Others
Protein ID: WP_043001559.1
Location: 1331779..1332330 (552 bp)
Type: Others
Protein ID: WP_044258934.1
Location: 1332507..1332725 (219 bp)
Type: Toxin
Protein ID: WP_001280991.1
Location: 1332753..1333127 (375 bp)
Type: Antitoxin
Protein ID: WP_042324455.1
Location: 1333639..1336788 (3150 bp)
Type: Others
Protein ID: WP_043001557.1
Location: 1336811..1338004 (1194 bp)
Type: Others
Protein ID: WP_043001556.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
M2R49_RS06305 (M2R49_06300)1328160..1328756+597WP_054176084.1membrane protein-
M2R49_RS06310 (M2R49_06305)1328839..1329192+354WP_043001561.1DUF1428 family protein-
M2R49_RS06315 (M2R49_06310)1329232..1330782-1551WP_054176085.1EAL domain-containing protein-
M2R49_RS06320 (M2R49_06315)1331005..1331145+141WP_003859006.1type B 50S ribosomal protein L36-
M2R49_RS06325 (M2R49_06320)1331195..1331665-471WP_043001559.1YlaC family protein-
M2R49_RS06330 (M2R49_06325)1331779..1332330-552WP_044258934.1maltose O-acetyltransferase-
M2R49_RS06335 (M2R49_06330)1332507..1332725-219WP_001280991.1HHA domain-containing proteinToxin
M2R49_RS06340 (M2R49_06335)1332753..1333127-375WP_042324455.1Hha toxicity modulator TomBAntitoxin
M2R49_RS06345 (M2R49_06340)1333639..1336788-3150WP_043001557.1efflux RND transporter permease AcrB-
M2R49_RS06350 (M2R49_06345)1336811..1338004-1194WP_043001556.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T244129 WP_001280991.1 NZ_CP096905:c1332725-1332507 [Citrobacter amalonaticus]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8989

>AT244129 WP_042324455.1 NZ_CP096905:c1333127-1332753 [Citrobacter amalonaticus]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB4ICG

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3Q8DH98

References