Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 152055..152590 Replicon plasmid pEC_RSHH22_1
Accession NZ_CP096903
Organism Escherichia coli strain RSHH22

Toxin (Protein)


Gene name relE Uniprot ID Q60228
Locus tag M1Y13_RS25790 Protein ID WP_001270417.1
Coordinates 152303..152590 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID L4J0V6
Locus tag M1Y13_RS25785 Protein ID WP_001132895.1
Coordinates 152055..152306 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1Y13_RS25765 (147884) 147884..149563 + 1680 WP_061892152.1 glycoside hydrolase family 43 protein -
M1Y13_RS25770 (150071) 150071..150253 + 183 Protein_166 IS3 family transposase -
M1Y13_RS25775 (150331) 150331..150603 + 273 WP_011310366.1 hypothetical protein -
M1Y13_RS25780 (150584) 150584..151789 + 1206 Protein_168 IS91 family transposase -
M1Y13_RS25785 (152055) 152055..152306 + 252 WP_001132895.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M1Y13_RS25790 (152303) 152303..152590 + 288 WP_001270417.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1Y13_RS25795 (152592) 152592..152870 + 279 Protein_171 integrase core domain-containing protein -
M1Y13_RS25800 (153505) 153505..154482 + 978 WP_061892150.1 RepB family plasmid replication initiator protein -
M1Y13_RS25805 (154761) 154761..155501 - 741 WP_001066941.1 tyrosine-type recombinase/integrase -
M1Y13_RS25810 (156502) 156502..157203 - 702 WP_263536092.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..161535 161535


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11214.24 Da        Isoelectric Point: 10.4703

>T244127 WP_001270417.1 NZ_CP096903:152303-152590 [Escherichia coli]
MRYQVKFREDALKEWQKLDKAIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9178.47 Da        Isoelectric Point: 4.2108

>AT244127 WP_001132895.1 NZ_CP096903:152055-152306 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8BSB4

Antitoxin

Source ID Structure
AlphaFold DB L4J0V6

References