Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4368165..4368760 Replicon chromosome
Accession NZ_CP096902
Organism Escherichia coli strain RSHH22

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M1Y13_RS21460 Protein ID WP_000239579.1
Coordinates 4368165..4368515 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M1Y13_RS21465 Protein ID WP_001223208.1
Coordinates 4368509..4368760 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1Y13_RS21440 (4363441) 4363441..4364463 - 1023 WP_001339490.1 ABC transporter permease -
M1Y13_RS21445 (4364477) 4364477..4365979 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
M1Y13_RS21450 (4366289) 4366289..4367245 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M1Y13_RS21455 (4367555) 4367555..4368085 + 531 WP_000055072.1 inorganic diphosphatase -
M1Y13_RS21460 (4368165) 4368165..4368515 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M1Y13_RS21465 (4368509) 4368509..4368760 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M1Y13_RS21470 (4368973) 4368973..4369314 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M1Y13_RS21475 (4369317) 4369317..4373096 - 3780 WP_000060901.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T244120 WP_000239579.1 NZ_CP096902:c4368515-4368165 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT244120 WP_001223208.1 NZ_CP096902:c4368760-4368509 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References