244117

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3705831..3706668 Replicon chromosome
Accession NZ_CP096902
Organism Escherichia coli strain RSHH22

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag M1Y13_RS18380 Protein ID WP_000227784.1
Coordinates 3706126..3706668 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag M1Y13_RS18375 Protein ID WP_001297137.1
Coordinates 3705831..3706142 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1Y13_RS18350 (3700851) 3700851..3701798 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
M1Y13_RS18355 (3701820) 3701820..3703811 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
M1Y13_RS18360 (3703801) 3703801..3704415 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
M1Y13_RS18365 (3704415) 3704415..3704744 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
M1Y13_RS18370 (3704756) 3704756..3705646 + 891 WP_000971336.1 heme o synthase -
M1Y13_RS18375 (3705831) 3705831..3706142 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
M1Y13_RS18380 (3706126) 3706126..3706668 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
M1Y13_RS18385 (3706724) 3706724..3707659 - 936 WP_001297127.1 tetratricopeptide repeat protein -
M1Y13_RS18390 (3708067) 3708067..3709431 + 1365 WP_001000978.1 MFS transporter -
M1Y13_RS18395 (3709559) 3709559..3710050 - 492 WP_129541729.1 nucleotide binding protein YajQ -
M1Y13_RS18400 (3710218) 3710218..3711129 + 912 WP_000705853.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T244117 WP_000227784.1 NZ_CP096902:3706126-3706668 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT244117 WP_001297137.1 NZ_CP096902:3705831-3706142 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References