Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3671742..3672360 Replicon chromosome
Accession NZ_CP096902
Organism Escherichia coli strain RSHH22

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M1Y13_RS18210 Protein ID WP_001291435.1
Coordinates 3672142..3672360 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M1Y13_RS18205 Protein ID WP_000344800.1
Coordinates 3671742..3672116 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1Y13_RS18195 (3666831) 3666831..3668024 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M1Y13_RS18200 (3668047) 3668047..3671196 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M1Y13_RS18205 (3671742) 3671742..3672116 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M1Y13_RS18210 (3672142) 3672142..3672360 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M1Y13_RS18215 (3672532) 3672532..3673083 + 552 WP_000102568.1 maltose O-acetyltransferase -
M1Y13_RS18220 (3673199) 3673199..3673669 + 471 WP_000136192.1 YlaC family protein -
M1Y13_RS18225 (3673833) 3673833..3675383 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M1Y13_RS18230 (3675425) 3675425..3675778 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M1Y13_RS18240 (3676157) 3676157..3676468 + 312 WP_000409911.1 MGMT family protein -
M1Y13_RS18245 (3676499) 3676499..3677071 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T244116 WP_001291435.1 NZ_CP096902:3672142-3672360 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT244116 WP_000344800.1 NZ_CP096902:3671742-3672116 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References