Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1439352..1439977 Replicon chromosome
Accession NZ_CP096902
Organism Escherichia coli strain RSHH22

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M1Y13_RS07090 Protein ID WP_000911330.1
Coordinates 1439579..1439977 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag M1Y13_RS07085 Protein ID WP_000450524.1
Coordinates 1439352..1439579 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1Y13_RS07060 (1435155) 1435155..1435625 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
M1Y13_RS07065 (1435625) 1435625..1436197 - 573 WP_000176191.1 glycine cleavage system transcriptional repressor -
M1Y13_RS07070 (1436343) 1436343..1437221 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
M1Y13_RS07075 (1437238) 1437238..1438272 + 1035 WP_001358397.1 outer membrane protein assembly factor BamC -
M1Y13_RS07080 (1438485) 1438485..1439198 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
M1Y13_RS07085 (1439352) 1439352..1439579 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
M1Y13_RS07090 (1439579) 1439579..1439977 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
M1Y13_RS07095 (1440124) 1440124..1440987 + 864 WP_001267508.1 neutral zinc metallopeptidase -
M1Y13_RS07100 (1441002) 1441002..1443017 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
M1Y13_RS07105 (1443091) 1443091..1443789 + 699 WP_000679823.1 esterase -
M1Y13_RS07110 (1443899) 1443899..1444099 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T244094 WP_000911330.1 NZ_CP096902:1439579-1439977 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT244094 WP_000450524.1 NZ_CP096902:1439352-1439579 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References