Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3132830..3133851 Replicon chromosome
Accession NZ_CP096893
Organism Proteus mirabilis strain 51661

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag M2R50_RS14345 Protein ID WP_004249488.1
Coordinates 3133282..3133851 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag M2R50_RS14340 Protein ID WP_004245528.1
Coordinates 3132830..3133282 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2R50_RS14320 (M2R50_14320) 3128616..3129146 - 531 WP_004245524.1 RNA pyrophosphohydrolase -
M2R50_RS14325 (M2R50_14325) 3129463..3130428 + 966 WP_020946190.1 thiamine ABC transporter substrate binding subunit -
M2R50_RS14330 (M2R50_14330) 3130428..3132008 + 1581 WP_046334723.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
M2R50_RS14335 (M2R50_14335) 3132001..3132702 + 702 WP_004245527.1 thiamine ABC transporter ATP-binding protein ThiQ -
M2R50_RS14340 (M2R50_14340) 3132830..3133282 + 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
M2R50_RS14345 (M2R50_14345) 3133282..3133851 + 570 WP_004249488.1 PIN domain-containing protein Toxin
M2R50_RS14350 (M2R50_14350) 3133967..3136321 + 2355 WP_017628571.1 DNA polymerase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21600.10 Da        Isoelectric Point: 7.3470

>T244085 WP_004249488.1 NZ_CP096893:3133282-3133851 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT244085 WP_004245528.1 NZ_CP096893:3132830-3133282 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References