Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 795692..796328 Replicon chromosome
Accession NZ_CP096886
Organism Rossellomorea sp. KS-H15a

Toxin (Protein)


Gene name mazF Uniprot ID A0A366ENG2
Locus tag M1J35_RS04010 Protein ID WP_034763063.1
Coordinates 795978..796328 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0V8H6B8
Locus tag M1J35_RS04005 Protein ID WP_032085355.1
Coordinates 795692..795973 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1J35_RS03985 (M1J35_03985) 791827..792411 - 585 WP_254652794.1 rhomboid family intramembrane serine protease -
M1J35_RS03990 (M1J35_03990) 792547..792897 + 351 WP_254652795.1 holo-ACP synthase -
M1J35_RS03995 (M1J35_03995) 793109..794122 + 1014 WP_254652796.1 outer membrane lipoprotein carrier protein LolA -
M1J35_RS04000 (M1J35_04000) 794360..795565 + 1206 WP_254652797.1 alanine racemase -
M1J35_RS04005 (M1J35_04005) 795692..795973 + 282 WP_032085355.1 YlcI/YnfO family protein Antitoxin
M1J35_RS04010 (M1J35_04010) 795978..796328 + 351 WP_034763063.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
M1J35_RS22665 796325..796459 - 135 WP_256503952.1 hypothetical protein -
M1J35_RS04015 (M1J35_04015) 796734..797564 + 831 WP_224521611.1 RsbT co-antagonist protein RsbRA -
M1J35_RS04020 (M1J35_04020) 797555..797917 + 363 WP_152968625.1 STAS domain-containing protein -
M1J35_RS04025 (M1J35_04025) 797920..798321 + 402 WP_034763056.1 anti-sigma regulatory factor -
M1J35_RS04030 (M1J35_04030) 798332..799342 + 1011 WP_224521610.1 PP2C family protein-serine/threonine phosphatase -
M1J35_RS04035 (M1J35_04035) 799417..799749 + 333 WP_224521609.1 anti-sigma factor antagonist -
M1J35_RS04040 (M1J35_04040) 799746..800216 + 471 WP_079532947.1 anti-sigma B factor RsbW -
M1J35_RS04045 (M1J35_04045) 800194..800991 + 798 WP_224521608.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13005.05 Da        Isoelectric Point: 5.1554

>T244082 WP_034763063.1 NZ_CP096886:795978-796328 [Rossellomorea sp. KS-H15a]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTIIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDDALQISVGLIQF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10780.23 Da        Isoelectric Point: 5.9021

>AT244082 WP_032085355.1 NZ_CP096886:795692-795973 [Rossellomorea sp. KS-H15a]
VSESSATTEILIRLPQQLVTELDGFADQENVNRNEFIYRATKMYLRERKKRQLRESMRRGYMEMAKINLAIASEAIQAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366ENG2

Antitoxin

Source ID Structure
AlphaFold DB A0A0V8H6B8

References