Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3771771..3772456 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag M1778_RS17700 Protein ID WP_003417998.1
Coordinates 3772046..3772456 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M1778_RS17695 Protein ID WP_003912220.1
Coordinates 3771771..3772049 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS17675 (M1778_17670) 3767760..3769361 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
M1778_RS17680 (M1778_17675) 3769378..3770082 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
M1778_RS17685 (M1778_17680) 3770200..3770766 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
M1778_RS17690 (M1778_17685) 3770828..3771715 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
M1778_RS17695 (M1778_17690) 3771771..3772049 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M1778_RS17700 (M1778_17695) 3772046..3772456 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
M1778_RS17705 (M1778_17700) 3772489..3774225 - 1737 WP_003418002.1 cholesterol oxidase -
M1778_RS17710 (M1778_17705) 3774281..3775408 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
M1778_RS17715 (M1778_17710) 3775428..3777017 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T244079 WP_003417998.1 NZ_CP096848:3772046-3772456 [Mycobacterium tuberculosis variant bovis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT244079 WP_003912220.1 NZ_CP096848:3771771-3772049 [Mycobacterium tuberculosis variant bovis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References