Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3744275..3744942 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag M1778_RS17575 Protein ID WP_003417916.1
Coordinates 3744275..3744667 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag M1778_RS17580 Protein ID WP_003912214.1
Coordinates 3744667..3744942 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS17560 (M1778_17555) 3739645..3741483 - 1839 WP_023349617.1 1-deoxy-D-xylulose-5-phosphate synthase -
M1778_RS17565 (M1778_17560) 3741480..3742469 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
M1778_RS17570 (M1778_17565) 3742469..3743521 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
M1778_RS17575 (M1778_17570) 3744275..3744667 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
M1778_RS17580 (M1778_17575) 3744667..3744942 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M1778_RS17585 (M1778_17580) 3745124..3746495 + 1372 Protein_3473 ISNCY family transposase -
M1778_RS17590 (M1778_17585) 3746685..3748937 + 2253 WP_011799349.1 PE family protein -
M1778_RS17595 (M1778_17590) 3749008..3749880 - 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3745818..3746495 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T244078 WP_003417916.1 NZ_CP096848:c3744667-3744275 [Mycobacterium tuberculosis variant bovis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT244078 WP_003912214.1 NZ_CP096848:c3744942-3744667 [Mycobacterium tuberculosis variant bovis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References