Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3717152..3717681 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag M1778_RS17455 Protein ID WP_003417760.1
Coordinates 3717424..3717681 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag M1778_RS17450 Protein ID WP_003417757.1
Coordinates 3717152..3717427 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS17415 (M1778_17410) 3713725..3714414 - 690 WP_003917774.1 BBE domain-containing protein -
M1778_RS17420 (M1778_17415) 3714601..3714972 - 372 WP_003417739.1 FAD-binding protein -
M1778_RS17425 (M1778_17420) 3714870..3715088 - 219 WP_157132559.1 hypothetical protein -
M1778_RS17430 (M1778_17425) 3715115..3715375 - 261 WP_003417741.1 hypothetical protein -
M1778_RS17435 (M1778_17430) 3715490..3715879 + 390 WP_010950876.1 DUF732 domain-containing protein -
M1778_RS17440 (M1778_17435) 3715893..3716186 - 294 WP_003417749.1 DUF3017 domain-containing protein -
M1778_RS17445 (M1778_17440) 3716183..3717028 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
M1778_RS17450 (M1778_17445) 3717152..3717427 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
M1778_RS17455 (M1778_17450) 3717424..3717681 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
M1778_RS17460 (M1778_17455) 3717723..3718913 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
M1778_RS17465 (M1778_17460) 3719030..3719398 + 369 WP_003417765.1 FHA domain-containing protein -
M1778_RS17470 (M1778_17465) 3719395..3719946 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
M1778_RS17475 (M1778_17470) 3719953..3720534 - 582 WP_003417769.1 ATP/GTP-binding protein -
M1778_RS17480 (M1778_17475) 3720515..3720883 - 369 WP_003417772.1 DUF742 domain-containing protein -
M1778_RS17485 (M1778_17480) 3720861..3721253 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T244077 WP_003417760.1 NZ_CP096848:3717424-3717681 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT244077 WP_003417757.1 NZ_CP096848:3717152-3717427 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References