Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3131655..3132342 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag M1778_RS14890 Protein ID WP_003414624.1
Coordinates 3131899..3132342 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag M1778_RS14885 Protein ID WP_003414620.1
Coordinates 3131655..3131912 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS14865 (M1778_14860) 3126975..3127829 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
M1778_RS14870 (M1778_14865) 3127885..3129048 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
M1778_RS14875 (M1778_14870) 3129065..3130279 - 1215 WP_003414610.1 zinc metalloprotease Rip -
M1778_RS14880 (M1778_14875) 3130287..3131528 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
M1778_RS14885 (M1778_14880) 3131655..3131912 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
M1778_RS14890 (M1778_14885) 3131899..3132342 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
M1778_RS14895 (M1778_14890) 3132422..3133084 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
M1778_RS14900 (M1778_14895) 3133180..3133371 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
M1778_RS14905 (M1778_14900) 3133703..3135451 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
M1778_RS14910 (M1778_14905) 3135547..3136128 + 582 WP_003414644.1 fasciclin domain-containing protein -
M1778_RS14915 (M1778_14910) 3136228..3136494 + 267 WP_031652375.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T244074 WP_003414624.1 NZ_CP096848:3131899-3132342 [Mycobacterium tuberculosis variant bovis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT244074 WP_003414620.1 NZ_CP096848:3131655-3131912 [Mycobacterium tuberculosis variant bovis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References