Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2766988..2767640 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag M1778_RS12965 Protein ID WP_003412752.1
Coordinates 2767215..2767640 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag M1778_RS12960 Protein ID WP_003412749.1
Coordinates 2766988..2767209 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS12945 (M1778_12940) 2765228..2765434 - 207 WP_003899347.1 hypothetical protein -
M1778_RS12950 (M1778_12945) 2765570..2766193 + 624 WP_003900858.1 TIGR00725 family protein -
M1778_RS12955 (M1778_12950) 2766183..2766935 + 753 WP_003901416.1 hypothetical protein -
M1778_RS12960 (M1778_12955) 2766988..2767209 + 222 WP_003412749.1 antitoxin Antitoxin
M1778_RS12965 (M1778_12960) 2767215..2767640 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
M1778_RS12970 (M1778_12965) 2767663..2768844 - 1182 WP_079367645.1 dihydrolipoamide acetyltransferase family protein -
M1778_RS12975 (M1778_12970) 2768841..2769887 - 1047 WP_010950730.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
M1778_RS12980 (M1778_12975) 2769898..2771001 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
M1778_RS12985 (M1778_12980) 2771260..2772081 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
M1778_RS12990 (M1778_12985) 2772078..2772635 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T244062 WP_003412752.1 NZ_CP096848:2767215-2767640 [Mycobacterium tuberculosis variant bovis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT244062 WP_003412749.1 NZ_CP096848:2766988-2767209 [Mycobacterium tuberculosis variant bovis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References