Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2337986..2338681 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag M1778_RS10905 Protein ID WP_003410811.1
Coordinates 2337986..2338420 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag M1778_RS10910 Protein ID WP_003410814.1
Coordinates 2338427..2338681 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS10895 (M1778_10895) 2334140..2337181 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
M1778_RS10900 (M1778_10900) 2337174..2338007 + 834 WP_003899172.1 SWIM zinc finger family protein -
M1778_RS10905 (M1778_10905) 2337986..2338420 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
M1778_RS10910 (M1778_10910) 2338427..2338681 - 255 WP_003410814.1 antitoxin Antitoxin
M1778_RS10915 (M1778_10915) 2338697..2338954 - 258 WP_003410816.1 hypothetical protein -
M1778_RS10920 (M1778_10920) 2339901..2340197 + 297 WP_003410820.1 PE family protein -
M1778_RS10925 (M1778_10925) 2340253..2340984 + 732 WP_003900467.1 PPE family protein -
M1778_RS10930 (M1778_10930) 2341524..2342270 - 747 WP_003901330.1 proteasome subunit alpha -
M1778_RS10935 (M1778_10935) 2342267..2343142 - 876 WP_003411023.1 proteasome subunit beta -
M1778_RS10940 (M1778_10940) 2343139..2343333 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T244060 WP_003410811.1 NZ_CP096848:c2338420-2337986 [Mycobacterium tuberculosis variant bovis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT244060 WP_003410814.1 NZ_CP096848:c2338681-2338427 [Mycobacterium tuberculosis variant bovis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References