Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2296808..2297444 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag M1778_RS10720 Protein ID WP_003410654.1
Coordinates 2297034..2297444 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag M1778_RS10715 Protein ID WP_003410651.1
Coordinates 2296808..2297041 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS10700 (M1778_10700) 2292256..2292657 + 402 WP_009937711.1 metal ABC transporter permease -
M1778_RS10705 (M1778_10705) 2292658..2293062 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
M1778_RS10710 (M1778_10710) 2293146..2296730 - 3585 WP_010950652.1 cobaltochelatase subunit CobN -
M1778_RS10715 (M1778_10715) 2296808..2297041 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
M1778_RS10720 (M1778_10720) 2297034..2297444 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
M1778_RS10725 (M1778_10725) 2297428..2298519 + 1092 WP_003900454.1 precorrin-3B synthase -
M1778_RS10730 (M1778_10730) 2298529..2299155 + 627 WP_003410658.1 precorrin-8X methylmutase -
M1778_RS10735 (M1778_10735) 2299152..2300678 + 1527 WP_079367717.1 precorrin-2 C(20)-methyltransferase -
M1778_RS10740 (M1778_10740) 2300624..2301847 - 1224 WP_079367718.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T244059 WP_003410654.1 NZ_CP096848:2297034-2297444 [Mycobacterium tuberculosis variant bovis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT244059 WP_003410651.1 NZ_CP096848:2296808-2297041 [Mycobacterium tuberculosis variant bovis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References