244056

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2203924..2204510 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag M1778_RS10315 Protein ID WP_003410010.1
Coordinates 2203924..2204268 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag M1778_RS10320 Protein ID WP_003410014.1
Coordinates 2204262..2204510 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS10280 (M1778_10280) 2199630..2200229 + 600 WP_003409989.1 L-lysine exporter -
M1778_RS10285 (M1778_10285) 2200645..2201073 + 429 WP_003409992.1 cellulose-binding protein -
M1778_RS10290 (M1778_10290) 2201299..2201838 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
M1778_RS10295 (M1778_10295) 2202358..2202918 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
M1778_RS10300 (M1778_10300) 2202915..2203256 - 342 WP_003410003.1 DUF2384 domain-containing protein -
M1778_RS10305 (M1778_10305) 2203342..2203599 + 258 WP_003410006.1 hypothetical protein -
M1778_RS10310 (M1778_10310) 2203500..2203835 - 336 WP_003410009.1 dehydrogenase -
M1778_RS10315 (M1778_10315) 2203924..2204268 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
M1778_RS10320 (M1778_10320) 2204262..2204510 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
M1778_RS10325 (M1778_10325) 2204610..2206925 - 2316 WP_003899120.1 cation transporter ATPase CptG -
M1778_RS10330 (M1778_10330) 2206922..2207194 - 273 WP_003410017.1 DUF1490 family protein -
M1778_RS10335 (M1778_10335) 2207247..2207603 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
M1778_RS10340 (M1778_10340) 2207760..2208527 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T244056 WP_003410010.1 NZ_CP096848:c2204268-2203924 [Mycobacterium tuberculosis variant bovis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT244056 WP_003410014.1 NZ_CP096848:c2204510-2204262 [Mycobacterium tuberculosis variant bovis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAW9

References