Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2202358..2203256 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag M1778_RS10295 Protein ID WP_003410001.1
Coordinates 2202358..2202918 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag M1778_RS10300 Protein ID WP_003410003.1
Coordinates 2202915..2203256 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS10265 (M1778_10265) 2197527..2198180 - 654 WP_003409976.1 cutinase Cfp21 -
M1778_RS10270 (M1778_10270) 2198295..2198525 + 231 WP_003409980.1 DUF167 domain-containing protein -
M1778_RS10275 (M1778_10275) 2198610..2199521 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
M1778_RS10280 (M1778_10280) 2199630..2200229 + 600 WP_003409989.1 L-lysine exporter -
M1778_RS10285 (M1778_10285) 2200645..2201073 + 429 WP_003409992.1 cellulose-binding protein -
M1778_RS10290 (M1778_10290) 2201299..2201838 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
M1778_RS10295 (M1778_10295) 2202358..2202918 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
M1778_RS10300 (M1778_10300) 2202915..2203256 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
M1778_RS10305 (M1778_10305) 2203342..2203599 + 258 WP_003410006.1 hypothetical protein -
M1778_RS10310 (M1778_10310) 2203500..2203835 - 336 WP_003410009.1 dehydrogenase -
M1778_RS10315 (M1778_10315) 2203924..2204268 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
M1778_RS10320 (M1778_10320) 2204262..2204510 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
M1778_RS10325 (M1778_10325) 2204610..2206925 - 2316 WP_003899120.1 cation transporter ATPase CptG -
M1778_RS10330 (M1778_10330) 2206922..2207194 - 273 WP_003410017.1 DUF1490 family protein -
M1778_RS10335 (M1778_10335) 2207247..2207603 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T244055 WP_003410001.1 NZ_CP096848:c2202918-2202358 [Mycobacterium tuberculosis variant bovis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT244055 WP_003410003.1 NZ_CP096848:c2203256-2202915 [Mycobacterium tuberculosis variant bovis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References