Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2195032..2195720 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag M1778_RS10250 Protein ID WP_003409958.1
Coordinates 2195032..2195451 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M1778_RS10255 Protein ID WP_079367672.1
Coordinates 2195460..2195720 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS10220 (M1778_10220) 2190038..2190343 + 306 Protein_2019 ABC transporter permease -
M1778_RS10225 (M1778_10225) 2190339..2190419 + 81 Protein_2020 hypothetical protein -
M1778_RS10230 (M1778_10230) 2190527..2191375 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
M1778_RS10235 (M1778_10235) 2191338..2192783 - 1446 WP_003409946.1 APC family permease -
M1778_RS10240 (M1778_10240) 2192962..2193648 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
M1778_RS10245 (M1778_10245) 2193839..2194807 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
M1778_RS10250 (M1778_10250) 2195032..2195451 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
M1778_RS10255 (M1778_10255) 2195460..2195720 - 261 WP_079367672.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1778_RS10260 (M1778_10260) 2195863..2197539 + 1677 WP_010950639.1 PecA family PE domain-processing aspartic protease -
M1778_RS10265 (M1778_10265) 2197527..2198180 - 654 WP_003409976.1 cutinase Cfp21 -
M1778_RS10270 (M1778_10270) 2198295..2198525 + 231 WP_003409980.1 DUF167 domain-containing protein -
M1778_RS10275 (M1778_10275) 2198610..2199521 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
M1778_RS10280 (M1778_10280) 2199630..2200229 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T244054 WP_003409958.1 NZ_CP096848:c2195451-2195032 [Mycobacterium tuberculosis variant bovis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9518.84 Da        Isoelectric Point: 5.1007

>AT244054 WP_079367672.1 NZ_CP096848:c2195720-2195460 [Mycobacterium tuberculosis variant bovis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSSITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure

References