Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2176981..2177684 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag M1778_RS10100 Protein ID WP_003409778.1
Coordinates 2176981..2177310 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag M1778_RS10105 Protein ID WP_003409780.1
Coordinates 2177307..2177684 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS10080 (M1778_10080) 2173364..2174434 + 1071 WP_003899091.1 epoxide hydrolase EphB -
M1778_RS10085 (M1778_10085) 2174431..2174946 + 516 WP_079367721.1 flavin reductase family protein -
M1778_RS10090 (M1778_10090) 2174943..2176004 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
M1778_RS10095 (M1778_10095) 2176001..2176771 + 771 WP_003409775.1 SDR family oxidoreductase -
M1778_RS10100 (M1778_10100) 2176981..2177310 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M1778_RS10105 (M1778_10105) 2177307..2177684 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
M1778_RS10110 (M1778_10110) 2177681..2178271 - 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
M1778_RS10115 (M1778_10115) 2178326..2179690 + 1365 WP_023642649.1 HNH endonuclease signature motif containing protein -
M1778_RS10120 (M1778_10120) 2179845..2180297 - 453 WP_010950636.1 lipoprotein -
M1778_RS10125 (M1778_10125) 2180361..2180762 + 402 WP_003409869.1 hypothetical protein -
M1778_RS10130 (M1778_10130) 2180755..2180937 - 183 WP_003409870.1 hypothetical protein -
M1778_RS10135 (M1778_10135) 2181051..2181401 - 351 WP_003409871.1 hypothetical protein -
M1778_RS10140 (M1778_10140) 2181412..2182314 - 903 WP_003409874.1 hypothetical protein -
M1778_RS10145 (M1778_10145) 2182335..2182526 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T244051 WP_003409778.1 NZ_CP096848:c2177310-2176981 [Mycobacterium tuberculosis variant bovis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT244051 WP_003409780.1 NZ_CP096848:c2177684-2177307 [Mycobacterium tuberculosis variant bovis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References