Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1943896..1944356 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag M1778_RS09090 Protein ID WP_003408531.1
Coordinates 1944108..1944356 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag M1778_RS09085 Protein ID WP_003408528.1
Coordinates 1943896..1944108 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS09070 (M1778_09070) 1940374..1941561 - 1188 WP_003898992.1 nitrate transporter NarK -
M1778_RS09075 (M1778_09075) 1941848..1942132 + 285 WP_003408522.1 DUF1876 domain-containing protein -
M1778_RS09080 (M1778_09080) 1942146..1943828 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
M1778_RS09085 (M1778_09085) 1943896..1944108 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1778_RS09090 (M1778_09090) 1944108..1944356 + 249 WP_003408531.1 hypothetical protein Toxin
M1778_RS09095 (M1778_09095) 1944364..1945102 + 739 Protein_1794 hypothetical protein -
M1778_RS09100 (M1778_09100) 1945196..1946896 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
M1778_RS09105 (M1778_09105) 1947181..1947582 - 402 WP_010950586.1 hypothetical protein -
M1778_RS09110 (M1778_09110) 1947572..1948183 - 612 Protein_1797 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T244050 WP_003408531.1 NZ_CP096848:1944108-1944356 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT244050 WP_003408528.1 NZ_CP096848:1943896-1944108 [Mycobacterium tuberculosis variant bovis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References