Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1923164..1923777 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag M1778_RS08980 Protein ID WP_003408465.1
Coordinates 1923164..1923553 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag M1778_RS08985 Protein ID WP_003408469.1
Coordinates 1923550..1923777 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS08945 (M1778_08945) 1918794..1919708 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
M1778_RS08950 (M1778_08950) 1919711..1920541 + 831 WP_003408448.1 cyclase family protein -
M1778_RS08955 (M1778_08955) 1920541..1920891 + 351 WP_003898986.1 cupin domain-containing protein -
M1778_RS08960 (M1778_08960) 1920944..1921761 + 818 Protein_1768 3-keto-5-aminohexanoate cleavage protein -
M1778_RS08965 (M1778_08965) 1921775..1922554 + 780 WP_003408460.1 IclR family transcriptional regulator -
M1778_RS08975 (M1778_08975) 1922985..1923116 + 132 Protein_1770 IS3 family transposase -
M1778_RS08980 (M1778_08980) 1923164..1923553 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
M1778_RS08985 (M1778_08985) 1923550..1923777 - 228 WP_003408469.1 antitoxin Antitoxin
M1778_RS08990 (M1778_08990) 1923995..1925479 + 1485 WP_010950580.1 biotin carboxylase -
M1778_RS08995 (M1778_08995) 1925476..1926723 + 1248 WP_003408476.1 serine hydrolase -
M1778_RS09000 (M1778_09000) 1926766..1927185 - 420 WP_003408483.1 hypothetical protein -
M1778_RS09005 (M1778_09005) 1927175..1927885 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T244049 WP_003408465.1 NZ_CP096848:c1923553-1923164 [Mycobacterium tuberculosis variant bovis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT244049 WP_003408469.1 NZ_CP096848:c1923777-1923550 [Mycobacterium tuberculosis variant bovis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References