Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1539461..1540511 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name phRel Uniprot ID -
Locus tag M1778_RS07305 Protein ID WP_079367706.1
Coordinates 1539461..1540282 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag M1778_RS07310 Protein ID WP_003407167.1
Coordinates 1540275..1540511 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS07285 (M1778_07285) 1535019..1535681 - 663 WP_010950531.1 hypothetical protein -
M1778_RS07290 (M1778_07290) 1535678..1536463 - 786 WP_079367705.1 hypothetical protein -
M1778_RS07295 (M1778_07295) 1536754..1538715 - 1962 WP_010950533.1 sigma-F factor regulator -
M1778_RS07300 (M1778_07300) 1538854..1539240 - 387 WP_003407162.1 anti-sigma-F factor antagonist RsfA -
M1778_RS07305 (M1778_07305) 1539461..1540282 + 822 WP_079367706.1 GTP pyrophosphokinase family protein Toxin
M1778_RS07310 (M1778_07310) 1540275..1540511 + 237 WP_003407167.1 hypothetical protein Antitoxin
M1778_RS07315 (M1778_07315) 1540583..1541788 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
M1778_RS07320 (M1778_07320) 1542091..1542876 + 786 WP_003407180.1 lipoprotein LprF -
M1778_RS07325 (M1778_07325) 1543072..1544542 + 1471 Protein_1442 cytochrome b5 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(53-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30114.13 Da        Isoelectric Point: 5.8187

>T244045 WP_079367706.1 NZ_CP096848:1539461-1540282 [Mycobacterium tuberculosis variant bovis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGIMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT244045 WP_003407167.1 NZ_CP096848:1540275-1540511 [Mycobacterium tuberculosis variant bovis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References