Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1391842..1392401 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag M1778_RS06665 Protein ID WP_003898789.1
Coordinates 1391842..1392135 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag M1778_RS06670 Protein ID WP_003406322.1
Coordinates 1392132..1392401 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS06640 (M1778_06635) 1387436..1387696 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
M1778_RS06645 (M1778_06640) 1387693..1388124 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
M1778_RS06650 (M1778_06645) 1388147..1389834 - 1688 Protein_1312 PE family protein -
M1778_RS06655 (M1778_06650) 1390014..1390874 + 861 WP_003406306.1 glycine betaine ABC transporter substrate-binding protein -
M1778_RS06660 (M1778_06655) 1390955..1391785 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
M1778_RS06665 (M1778_06660) 1391842..1392135 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
M1778_RS06670 (M1778_06665) 1392132..1392401 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M1778_RS06675 (M1778_06670) 1392514..1396209 - 3696 WP_010950509.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
M1778_RS06680 (M1778_06675) 1396351..1397139 - 789 WP_010950510.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T244044 WP_003898789.1 NZ_CP096848:c1392135-1391842 [Mycobacterium tuberculosis variant bovis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT244044 WP_003406322.1 NZ_CP096848:c1392401-1392132 [Mycobacterium tuberculosis variant bovis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References