Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1387436..1388124 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag M1778_RS06645 Protein ID WP_003406304.1
Coordinates 1387693..1388124 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag M1778_RS06640 Protein ID WP_003406302.1
Coordinates 1387436..1387696 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS06620 (M1778_06615) 1383013..1383837 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
M1778_RS06625 (M1778_06620) 1383842..1385023 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
M1778_RS06630 (M1778_06625) 1385100..1386200 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
M1778_RS06635 (M1778_06630) 1386371..1387360 + 990 WP_003406301.1 malate dehydrogenase -
M1778_RS06640 (M1778_06635) 1387436..1387696 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
M1778_RS06645 (M1778_06640) 1387693..1388124 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
M1778_RS06650 (M1778_06645) 1388147..1389834 - 1688 Protein_1312 PE family protein -
M1778_RS06655 (M1778_06650) 1390014..1390874 + 861 WP_003406306.1 glycine betaine ABC transporter substrate-binding protein -
M1778_RS06660 (M1778_06655) 1390955..1391785 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
M1778_RS06665 (M1778_06660) 1391842..1392135 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
M1778_RS06670 (M1778_06665) 1392132..1392401 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T244043 WP_003406304.1 NZ_CP096848:1387693-1388124 [Mycobacterium tuberculosis variant bovis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT244043 WP_003406302.1 NZ_CP096848:1387436-1387696 [Mycobacterium tuberculosis variant bovis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References