Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1233866..1234497 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag M1778_RS05915 Protein ID WP_003405820.1
Coordinates 1233866..1234177 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag M1778_RS05920 Protein ID WP_003405836.1
Coordinates 1234177..1234497 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS05895 (M1778_05895) 1229348..1230772 - 1425 WP_003405805.1 class II fumarate hydratase -
M1778_RS05900 (M1778_05900) 1230803..1231891 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
M1778_RS05905 (M1778_05905) 1231947..1232591 + 645 WP_003915494.1 DUF4245 domain-containing protein -
M1778_RS05910 (M1778_05910) 1232598..1233754 - 1157 Protein_1164 AI-2E family transporter -
M1778_RS05915 (M1778_05915) 1233866..1234177 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
M1778_RS05920 (M1778_05920) 1234177..1234497 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
M1778_RS05925 (M1778_05925) 1234507..1236043 + 1537 Protein_1167 carboxylesterase/lipase family protein -
M1778_RS05930 (M1778_05930) 1236050..1237162 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
M1778_RS05935 (M1778_05935) 1237172..1237429 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
M1778_RS05940 (M1778_05940) 1237419..1238666 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
M1778_RS05945 (M1778_05945) 1238663..1239301 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T244041 WP_003405820.1 NZ_CP096848:c1234177-1233866 [Mycobacterium tuberculosis variant bovis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT244041 WP_003405836.1 NZ_CP096848:c1234497-1234177 [Mycobacterium tuberculosis variant bovis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References