24404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 818024..818501 Replicon chromosome
Accession NC_013450
Organism Staphylococcus aureus subsp. aureus ED98

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAAV_RS03955 Protein ID WP_000052076.1
Coordinates 818024..818212 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAAV_RS03960 Protein ID WP_001059690.1
Coordinates 818241..818501 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAAV_RS03925 814018..814539 + 522 WP_000824481.1 hypothetical protein -
SAAV_RS03930 814880..815566 + 687 WP_000141557.1 thermonuclease family protein -
SAAV_RS03935 815923..816123 + 201 WP_001059082.1 cold-shock protein -
SAAV_RS03940 816615..816833 - 219 WP_000005886.1 hypothetical protein -
SAAV_RS03945 816895..817179 - 285 WP_001004399.1 hypothetical protein -
SAAV_RS03950 817267..817836 - 570 WP_001106654.1 hypothetical protein -
SAAV_RS03955 818024..818212 - 189 WP_000052076.1 hypothetical protein Toxin
SAAV_RS03960 818241..818501 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAAV_RS03965 818842..819045 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAAV_RS03970 819042..819278 - 237 WP_000349581.1 hypothetical protein -
SAAV_RS03975 819503..820084 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAAV_RS03980 820157..820774 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
SAAV_RS03985 820929..821423 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAAV_RS03990 821822..822244 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAAV_RS03995 822392..823108 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T24404 WP_000052076.1 NC_013450:c818212-818024 [Staphylococcus aureus subsp. aureus ED98]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T24404 NC_013450:c818212-818024 [Staphylococcus aureus subsp. aureus ED98]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT24404 WP_001059690.1 NC_013450:c818501-818241 [Staphylococcus aureus subsp. aureus ED98]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT24404 NC_013450:c818501-818241 [Staphylococcus aureus subsp. aureus ED98]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References