Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 713168..713793 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag M1778_RS03270 Protein ID WP_003403218.1
Coordinates 713392..713793 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag M1778_RS03265 Protein ID WP_003403213.1
Coordinates 713168..713395 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS03240 (M1778_03240) 708347..708568 - 222 WP_003898525.1 DUF4926 domain-containing protein -
M1778_RS03245 (M1778_03245) 708710..709315 + 606 WP_003898526.1 hypothetical protein -
M1778_RS03250 (M1778_03250) 709334..711901 - 2568 WP_079367682.1 SEC-C metal-binding domain-containing protein -
M1778_RS03255 (M1778_03255) 711985..712734 + 750 WP_003898528.1 hypothetical protein -
M1778_RS03260 (M1778_03260) 712731..712973 + 243 WP_003403210.1 hypothetical protein -
M1778_RS03265 (M1778_03265) 713168..713395 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
M1778_RS03270 (M1778_03270) 713392..713793 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
M1778_RS03275 (M1778_03275) 713922..714005 + 84 Protein_649 galactose-1-phosphate uridylyltransferase -
M1778_RS03280 (M1778_03280) 714024..715106 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
M1778_RS03285 (M1778_03285) 715103..716194 + 1092 WP_003403225.1 galactokinase -
M1778_RS03290 (M1778_03290) 716589..717746 + 1158 WP_003903091.1 hypothetical protein -
M1778_RS03295 (M1778_03295) 717757..718704 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T244030 WP_003403218.1 NZ_CP096848:713392-713793 [Mycobacterium tuberculosis variant bovis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT244030 WP_003403213.1 NZ_CP096848:713168-713395 [Mycobacterium tuberculosis variant bovis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References