Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5165886..5167576 Replicon chromosome
Accession NC_013446
Organism Comamonas testosteroni CNB-2

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CTCNB1_RS23500 Protein ID WP_012840245.1
Coordinates 5166698..5167576 (-) Length 293 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CTCNB1_RS23495 Protein ID WP_041744376.1
Coordinates 5165886..5166692 (-) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTCNB1_RS23470 5161030..5161887 - 858 WP_012840239.1 IclR family transcriptional regulator -
CTCNB1_RS23475 5161895..5162671 - 777 WP_012840240.1 SDR family oxidoreductase -
CTCNB1_RS23480 5162986..5163744 - 759 WP_012840241.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
CTCNB1_RS23485 5163864..5164850 - 987 WP_012840242.1 tripartite tricarboxylate transporter substrate binding protein -
CTCNB1_RS23490 5165043..5165843 - 801 WP_012840243.1 aspartate dehydrogenase -
CTCNB1_RS23495 5165886..5166692 - 807 WP_041744376.1 IclR family transcriptional regulator Antitoxin
CTCNB1_RS23500 5166698..5167576 - 879 WP_012840245.1 alpha/beta hydrolase Toxin
CTCNB1_RS23505 5167585..5168118 - 534 WP_003072476.1 cupin domain-containing protein -
CTCNB1_RS23510 5168380..5170056 - 1677 WP_012840246.1 long-chain-fatty-acid--CoA ligase -
CTCNB1_RS23515 5170270..5171334 - 1065 WP_004340312.1 fructose-bisphosphate aldolase class II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(44-277)

Antitoxin

Transcription regulator IclR, N-terminal

(19-69)


Sequences

Toxin        


Download         Length: 293 a.a.        Molecular weight: 30689.20 Da        Isoelectric Point: 6.6011

>T24403 WP_012840245.1 NC_013446:c5167576-5166698 [Comamonas thiooxydans]
MHEDLLSLKQQLLQTGFPERLVKLPQKAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALQLGDKARVLAWDAPGYGV
STPLAQSAPADADYAQVLAQSLLVLGVRRCLLVGHSLGALMAARLAVTAAPGLVEQLVLISPAGGYGAPAKAEQQAKVRE
GRLAALAEKGVAGLAAVIDQRLVSSEAPEAVRAWVRWNTARMQPQGYAQAVELLCGSDLAQARGRLGMPVEVWVGEHDVV
TTPAACKSWSEMLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS

Download         Length: 879 bp

>T24403 NC_013446:c5167576-5166698 [Comamonas thiooxydans]
ATGCACGAGGATTTGCTGTCGCTGAAACAGCAGCTGCTGCAGACCGGTTTTCCCGAGCGGCTGGTGAAGCTTCCGCAGAA
GGCCCAGGTCGCCTGGCGCGAGGCTGGCGACGCCAGCTCCGATTTTGCGGTGGTGCTGCTGCATGGCATCAGCTCCGGGG
CTGCATCCTGGCTGGATGTGGCGCTGCAGCTGGGTGACAAGGCGCGCGTCCTGGCCTGGGATGCACCCGGCTATGGCGTG
TCGACGCCGCTGGCCCAATCGGCGCCTGCCGATGCCGACTATGCGCAGGTGCTGGCCCAGTCACTGCTGGTGCTCGGTGT
GCGGCGCTGCCTGCTGGTCGGCCATTCCCTGGGCGCCCTGATGGCGGCCAGGCTGGCAGTCACGGCGGCCCCCGGGCTGG
TCGAGCAACTGGTGCTCATCAGCCCGGCGGGCGGCTACGGCGCCCCAGCCAAGGCCGAGCAGCAGGCCAAGGTACGCGAG
GGCCGCCTGGCGGCTCTGGCCGAGAAGGGCGTCGCCGGTCTGGCGGCCGTCATCGATCAGCGCCTGGTGTCCTCCGAGGC
TCCTGAAGCCGTGCGTGCATGGGTGCGCTGGAATACGGCGCGCATGCAGCCGCAGGGCTATGCGCAGGCGGTCGAGCTGC
TTTGCGGCAGCGATCTGGCACAGGCACGGGGCAGGCTTGGCATGCCGGTCGAGGTTTGGGTCGGCGAGCACGATGTGGTG
ACTACACCTGCAGCTTGCAAGTCCTGGTCCGAAATGCTGGGCGCGCACTACGGTACGCTTGCGGCTGCCGGTCATGCTTC
ACCCGTGGAACAACCAATGGAGGTCGCGCATAGGCTGGCATCTTTGTTGAACCAAAGCTATTGCCCCAATACCAGCTGA

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29245.19 Da        Isoelectric Point: 5.3764

>AT24403 WP_041744376.1 NC_013446:c5166692-5165886 [Comamonas thiooxydans]
MSETSEISTNEQDRYTVPALDRGLRLLACFGPAQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNIDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGRVVAGLAMAIPFTELGPDK
TQLWVQKVQQAAETLSAHLRQQHPDHLR

Download         Length: 807 bp

>AT24403 NC_013446:c5166692-5165886 [Comamonas thiooxydans]
ATGAGCGAAACCTCCGAGATTTCAACCAACGAACAAGACCGTTACACCGTGCCCGCTCTGGACCGAGGACTGCGCCTGCT
GGCCTGCTTTGGCCCGGCGCAACCGGTCTGGAGCGCACCCGAGCTGGCACGCAGCCTCGAGCTGCCGCGCTCCACGGTGT
TTCGCATGTTGACCACGCTTGAAAACTCGGGGTATCTGCAGCGCAGCGGCACCGAATACCGGCTCGGTCTGGCCGTGCTG
CGCCTGGGCTATGACTACCTGTCCACCCAGCCGCTGGCGCAACTGGCCGAGCCTGTGCTGCAGGCCTTGTGCGATGAGCT
GGGCATGACCAGCAATCTTGCATTGCGCGACGGCACTTCCGTGGTCTATGTGGCACGCGTCACTCCGTCCGGAGCATTCC
AGGGCGCTGTGCGCGTGGGTTCGCGTCTGCCGGCGCACGCGACGGTGCTGGGACGAGCCCTGTTGCATGACATGGACGGC
GCGCAGCTGCGCTCGGTGTTTGGTGGCGAGGAACTGCCCCAGTTCTCCGAGAGCACGCCGCGCAATATCGACGAGCTGCT
GCGCCTGCTGGCCGAGGATCGCGAGCGCGGCTATGCCATGGGCGAGGGCTTTTACGAGCCTGGCGTTTCGAGTATTGCAG
CGCCGGTGCGCGCCGCAGACGGGCGGGTGGTTGCGGGGCTGGCCATGGCCATTCCGTTTACCGAGCTGGGGCCCGATAAA
ACCCAGCTCTGGGTGCAGAAGGTGCAGCAGGCGGCAGAGACTCTGTCCGCTCATTTGCGCCAGCAGCACCCGGACCATTT
GCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References