Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 364183..364709 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag M1778_RS01590 Protein ID WP_003401560.1
Coordinates 364407..364709 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID P9WJ08
Locus tag M1778_RS01585 Protein ID WP_003401555.1
Coordinates 364183..364410 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS01570 (M1778_01570) 359831..360634 - 804 WP_003401540.1 Stf0 family sulphotransferase -
M1778_RS01575 (M1778_01575) 360644..362041 - 1398 WP_079367724.1 sulfatase -
M1778_RS01580 (M1778_01580) 362220..364040 + 1821 WP_003401546.1 PE family protein -
M1778_RS01585 (M1778_01585) 364183..364410 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family Antitoxin
M1778_RS01590 (M1778_01590) 364407..364709 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
M1778_RS01595 (M1778_01595) 364757..364978 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
M1778_RS01600 (M1778_01600) 364975..365400 + 426 WP_003401566.1 PIN domain nuclease -
M1778_RS01605 (M1778_01605) 365536..366168 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
M1778_RS01610 (M1778_01610) 366165..367073 + 909 WP_003900117.1 protochlorophyllide reductase -
M1778_RS01615 (M1778_01615) 367081..367671 - 591 WP_234712434.1 hypothetical protein -
M1778_RS01620 (M1778_01620) 367664..367714 - 51 Protein_320 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T244022 WP_003401560.1 NZ_CP096848:364407-364709 [Mycobacterium tuberculosis variant bovis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8130.21 Da        Isoelectric Point: 7.0084

>AT244022 WP_003401555.1 NZ_CP096848:364183-364410 [Mycobacterium tuberculosis variant bovis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4F8T1

References