Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2573112..2574648 Replicon chromosome
Accession NC_013446
Organism Comamonas testosteroni CNB-2

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag CTCNB1_RS11610 Protein ID WP_012838314.1
Coordinates 2573350..2574648 (+) Length 433 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag CTCNB1_RS11605 Protein ID WP_012838313.1
Coordinates 2573112..2573360 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTCNB1_RS11590 2569812..2570686 + 875 Protein_2260 hypothetical protein -
CTCNB1_RS11595 2570779..2572617 + 1839 WP_012838311.1 dihydrolipoyl dehydrogenase -
CTCNB1_RS11600 2572782..2572940 + 159 WP_041744108.1 hypothetical protein -
CTCNB1_RS11605 2573112..2573360 + 249 WP_012838313.1 helix-turn-helix transcriptional regulator Antitoxin
CTCNB1_RS11610 2573350..2574648 + 1299 WP_012838314.1 type II toxin-antitoxin system HipA family toxin Toxin
CTCNB1_RS11615 2574882..2575358 + 477 WP_080692925.1 GFA family protein -
CTCNB1_RS11620 2575491..2576861 - 1371 WP_012838316.1 MFS transporter -
CTCNB1_RS11625 2577667..2578023 - 357 WP_041744109.1 alkylphosphonate utilization protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-60)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 47029.09 Da        Isoelectric Point: 7.2921

>T24401 WP_012838314.1 NC_013446:2573350-2574648 [Comamonas thiooxydans]
MTHELEVWLFDERVGSLSLVHGRLSFAYATDWLALPQATALSQSLPLQAKPFDDHQTRPFFAGLLPEGQMRRLIAQQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPQTNGAGATGAPGDVEWLSDQKLLALLDELPRRPMLAGDDGLRLSLAGAQD
KLPVVVDESIPGAVRIGLPRNGAPSSHILKPAIHAVEDSVANEGFCMLLAQVMGLRPANARIQSVLGRSFLLVKRYDREL
NAQDLHQPQLQRLHQEDFCQALGVVPELKYQNEGGPGLAQCFALLRSVTRPSAPQVLRLLDGAIFNALIGNHDAHGKNFS
LLYGGRAPVLAPFYDLLATAIYPQLTPKMAMKIGSKYKFSELEARHWEQFAEEAGLAKAATRKRLQQLANELPAAARKLQ
AAPPHGFAGNAVVTQIVQLIEQRCALTLRRLA

Download         Length: 1299 bp

>T24401 NC_013446:2573350-2574648 [Comamonas thiooxydans]
ATGACGCATGAACTCGAAGTCTGGCTGTTTGATGAGCGCGTCGGCAGTCTGTCGCTGGTGCATGGGCGGCTGAGCTTTGC
CTATGCGACCGACTGGTTGGCGCTGCCGCAGGCCACGGCTTTATCGCAGTCGCTGCCGCTGCAGGCTAAACCTTTTGACG
ATCATCAGACCCGGCCGTTCTTCGCCGGTCTGCTGCCCGAGGGGCAGATGCGGCGCCTGATTGCCCAGCAGTTTCAGGTG
TCGGGCCAAAACGATTTTGCGCTGCTGGACCATATTGGCGGCGAATGCGCGGGGGCCGTGACCTTTCTGGAGCCGGGGCA
GGCCTTGCCGCAGACTAACGGGGCTGGGGCGACCGGGGCACCGGGTGATGTGGAGTGGCTCAGCGATCAAAAGCTGCTCG
CCTTGCTGGACGAGCTGCCGCGTCGCCCCATGCTGGCGGGAGATGACGGGCTGCGGCTATCGCTGGCAGGGGCGCAGGAC
AAGTTGCCCGTGGTGGTGGACGAGAGCATTCCGGGCGCAGTGCGTATCGGTCTGCCGCGTAACGGCGCGCCCAGCTCGCA
TATCTTGAAGCCCGCCATCCATGCGGTGGAGGACAGTGTGGCCAATGAAGGCTTTTGCATGCTGCTGGCCCAGGTCATGG
GGCTGCGGCCTGCCAATGCCCGAATCCAGAGCGTGCTGGGCCGCTCGTTTTTGCTGGTGAAGCGCTATGACCGGGAGCTG
AATGCTCAAGATCTGCACCAGCCGCAGTTGCAACGTCTGCATCAGGAAGACTTTTGTCAGGCGCTGGGCGTGGTGCCCGA
GCTGAAGTACCAGAACGAGGGCGGGCCGGGCCTGGCGCAATGCTTTGCCCTGCTGCGCAGCGTGACCCGGCCCAGCGCGC
CTCAGGTGCTGCGGCTGCTGGATGGGGCGATCTTCAATGCCTTGATTGGCAACCATGATGCCCATGGCAAGAATTTCTCG
CTGCTTTATGGGGGAAGGGCGCCCGTGCTGGCACCGTTCTACGACCTGCTGGCTACAGCGATTTACCCCCAGCTGACGCC
CAAGATGGCAATGAAGATTGGCAGCAAATACAAGTTCAGCGAGCTGGAGGCCAGGCACTGGGAGCAGTTTGCGGAAGAAG
CAGGCCTTGCCAAGGCGGCGACGCGCAAGCGTTTGCAGCAGCTGGCGAACGAACTACCCGCTGCCGCGCGCAAGCTGCAG
GCCGCGCCACCGCATGGTTTTGCGGGCAATGCCGTGGTGACGCAGATCGTGCAGCTGATAGAGCAGCGCTGCGCCTTGAC
GCTGAGGCGCTTGGCCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8529.72 Da        Isoelectric Point: 5.6051

>AT24401 WP_012838313.1 NC_013446:2573112-2573360 [Comamonas thiooxydans]
MSTIQTTEQLGAALRTARKQLGLTQPQLALAAGVGTRFIVDLEAGKPTVRLEHVLRVIDALGGELQLGGLPNTASEGADH
DA

Download         Length: 249 bp

>AT24401 NC_013446:2573112-2573360 [Comamonas thiooxydans]
ATGTCCACCATCCAAACAACCGAGCAATTGGGCGCGGCCTTGCGCACCGCCCGTAAACAACTGGGGCTGACCCAGCCCCA
GCTTGCCTTGGCCGCAGGCGTGGGCACGCGTTTTATTGTGGATCTCGAGGCTGGCAAGCCCACGGTGCGGCTGGAGCATG
TGCTGCGGGTGATCGATGCGCTGGGCGGGGAGTTGCAGTTGGGCGGCTTGCCGAATACAGCTTCTGAGGGCGCAGACCAT
GACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References