244007

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2835861..2836498 Replicon chromosome
Accession NZ_CP096847
Organism Mycobacterium tuberculosis variant bovis strain Mb0531

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag M1773_RS13300 Protein ID WP_003413180.1
Coordinates 2835861..2836256 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag M1773_RS13305 Protein ID WP_003413183.1
Coordinates 2836253..2836498 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1773_RS13260 (M1773_13260) 2831946..2832605 + 660 WP_003900846.1 LppA family lipoprotein -
M1773_RS13265 (M1773_13265) 2832602..2833261 + 660 WP_003900847.1 LppA family lipoprotein -
M1773_RS13270 (M1773_13270) 2833258..2833920 + 663 WP_003900848.1 LppA family lipoprotein -
M1773_RS13275 (M1773_13275) 2833917..2834195 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
M1773_RS13280 (M1773_13280) 2834288..2834701 + 414 WP_003413164.1 PIN domain nuclease -
M1773_RS13285 (M1773_13285) 2834740..2834997 + 258 WP_003413167.1 CopG family transcriptional regulator -
M1773_RS13290 (M1773_13290) 2834994..2835371 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
M1773_RS13295 (M1773_13295) 2835387..2835761 - 375 WP_003413177.1 hypothetical protein -
M1773_RS13300 (M1773_13300) 2835861..2836256 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
M1773_RS13305 (M1773_13305) 2836253..2836498 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
M1773_RS13310 (M1773_13310) 2836909..2837328 - 420 WP_003413190.1 A24 family peptidase -
M1773_RS13315 (M1773_13315) 2837340..2838148 - 809 Protein_2628 shikimate dehydrogenase -
M1773_RS13320 (M1773_13320) 2838145..2839398 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
M1773_RS13325 (M1773_13325) 2839391..2839903 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T244007 WP_003413180.1 NZ_CP096847:c2836256-2835861 [Mycobacterium tuberculosis variant bovis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT244007 WP_003413183.1 NZ_CP096847:c2836498-2836253 [Mycobacterium tuberculosis variant bovis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References