244004

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2819745..2820385 Replicon chromosome
Accession NZ_CP096847
Organism Mycobacterium tuberculosis variant bovis strain Mb0531

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag M1773_RS13190 Protein ID WP_003412970.1
Coordinates 2819745..2820164 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag M1773_RS13195 Protein ID WP_003412975.1
Coordinates 2820161..2820385 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1773_RS13160 (M1773_13160) 2815330..2816052 - 723 WP_003412957.1 DUF1906 domain-containing protein -
M1773_RS13165 (M1773_13165) 2816569..2816796 + 228 WP_003412960.1 type II toxin-antitoxin system VapB family antitoxin -
M1773_RS13170 (M1773_13170) 2816793..2817194 + 402 WP_003412963.1 PIN domain-containing protein -
M1773_RS13175 (M1773_13175) 2817229..2818149 - 921 WP_003412965.1 restriction endonuclease -
M1773_RS13180 (M1773_13180) 2818490..2818696 - 207 WP_234712436.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
M1773_RS13185 (M1773_13185) 2818794..2819744 + 951 WP_003911916.1 ERCC4 domain-containing protein -
M1773_RS13190 (M1773_13190) 2819745..2820164 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
M1773_RS13195 (M1773_13195) 2820161..2820385 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
M1773_RS13200 (M1773_13200) 2820416..2823259 - 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
M1773_RS13205 (M1773_13205) 2823331..2823732 - 402 WP_003412981.1 hypothetical protein -
M1773_RS13210 (M1773_13210) 2823732..2824202 - 471 WP_003412985.1 transcription antitermination factor NusB -
M1773_RS13215 (M1773_13215) 2824205..2824768 - 564 WP_003412989.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T244004 WP_003412970.1 NZ_CP096847:c2820164-2819745 [Mycobacterium tuberculosis variant bovis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT244004 WP_003412975.1 NZ_CP096847:c2820385-2820161 [Mycobacterium tuberculosis variant bovis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ08

Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References