Detailed information of TA system TA024400

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2831889..2832451
• Replicon: chromosome
• Accession: NC_013441
• Organism: Gordonia bronchialis DSM 43247

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D0LF01
• Locus tag: GBRO_RS13115
• Protein ID: WP_012834418.1
• Coordinates: 2831889..2832179 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D0L7Y1
• Locus tag: GBRO_RS13120
• Protein ID: WP_012834419.1
• Coordinates: 2832176..2832451 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GBRO_RS13110	2831569..2831847	-	279	WP_012834417.1	hypothetical protein	-
GBRO_RS13115	2831889..2832179	-	291	WP_012834418.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GBRO_RS13120	2832176..2832451	-	276	WP_012834419.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GBRO_RS13130	2833349..2833990	-	642	WP_005179592.1	organomercurial lyase MerB	-
GBRO_RS13135	2833932..2834483	-	552	WP_005179589.1	MerR family transcriptional regulator	-
GBRO_RS13140	2834508..2835944	-	1437	WP_012834420.1	mercury(II) reductase	-
GBRO_RS13145	2836069..2836446	+	378	WP_005179587.1	metalloregulator ArsR/SmtB family transcription factor	-
GBRO_RS13155	2837059..2837280	-	222	WP_005179582.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2785464..2832451	46987

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (14-94)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10746.28 Da
• Isoelectric Point: 11.1310

>T24400 WP_012834418.1 NC_013441:c2832179-2831889 [Gordonia bronchialis DSM 43247]
MSDAPTDSPAPYRVEVASPARRDLQRLPSRIVHAVIEFISGPLAGNPHRLSKPLRDDLGGLHSARRGDYRILLRIDAPNH
TIVVVRIDHRAHAYRT

Nucleotide

• Length: 291 bp

>T24400 NC_013441:c2832179-2831889 [Gordonia bronchialis DSM 43247]
ATGAGCGACGCTCCGACAGACTCGCCCGCCCCATACCGGGTCGAGGTCGCATCCCCAGCTCGCCGCGACCTTCAACGACT
TCCATCCCGGATCGTCCACGCCGTCATCGAATTCATCTCCGGACCTCTCGCTGGCAACCCTCACCGGCTCAGCAAACCGC
TGCGCGACGACCTCGGAGGCCTCCACAGCGCCCGCCGCGGCGACTACCGCATCCTGCTCCGCATCGACGCCCCCAACCAC
ACCATCGTTGTCGTCAGAATCGACCACCGCGCCCACGCATATCGCACCTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9726.88 Da
• Isoelectric Point: 4.6221

>AT24400 WP_012834419.1 NC_013441:c2832451-2832176 [Gordonia bronchialis DSM 43247]
MTTVPLGEAKDKLSALIDSAETTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRAGVRDDVATADAEYAAGHTASID
DLRAEHGMPPK

Nucleotide

• Length: 276 bp

>AT24400 NC_013441:c2832451-2832176 [Gordonia bronchialis DSM 43247]
ATGACGACAGTGCCACTCGGCGAGGCCAAGGACAAGCTCTCCGCGCTCATCGACAGCGCCGAAACCACGCACGACATCAT
CACGATCACCAAGCACGGCAAACCCGCTGCGGTGCTGATGTCGGCCGACGACCTCGAATCGCTGCACGAGACGATCTACT
GGCTCTCACGTGCCGGCGTCCGCGACGACGTCGCCACCGCCGACGCCGAGTACGCCGCCGGCCACACCGCCTCCATCGAC
GACCTGCGCGCCGAACACGGTATGCCGCCGAAATGA

Structures

Toxin

• AlphaFold DB: D0LF01

Antitoxin

• AlphaFold DB: D0L7Y1