243996

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2208873..2209771 Replicon chromosome
Accession NZ_CP096847
Organism Mycobacterium tuberculosis variant bovis strain Mb0531

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag M1773_RS10325 Protein ID WP_003410001.1
Coordinates 2208873..2209433 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag M1773_RS10330 Protein ID WP_003410003.1
Coordinates 2209430..2209771 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1773_RS10295 (M1773_10300) 2204042..2204695 - 654 WP_003409976.1 cutinase Cfp21 -
M1773_RS10300 (M1773_10305) 2204810..2205040 + 231 WP_003409980.1 DUF167 domain-containing protein -
M1773_RS10305 (M1773_10310) 2205125..2206036 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
M1773_RS10310 (M1773_10315) 2206145..2206744 + 600 WP_003409989.1 L-lysine exporter -
M1773_RS10315 (M1773_10320) 2207160..2207588 + 429 WP_003409992.1 cellulose-binding protein -
M1773_RS10320 (M1773_10325) 2207814..2208353 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
M1773_RS10325 (M1773_10330) 2208873..2209433 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
M1773_RS10330 (M1773_10335) 2209430..2209771 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
M1773_RS10335 (M1773_10340) 2209857..2210114 + 258 WP_003410006.1 hypothetical protein -
M1773_RS10340 (M1773_10345) 2210015..2210350 - 336 WP_003410009.1 dehydrogenase -
M1773_RS10345 (M1773_10350) 2210439..2210783 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
M1773_RS10350 (M1773_10355) 2210777..2211025 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
M1773_RS10355 (M1773_10360) 2211125..2213440 - 2316 WP_003899120.1 cation transporter ATPase CptG -
M1773_RS10360 (M1773_10365) 2213437..2213709 - 273 WP_003410017.1 DUF1490 family protein -
M1773_RS10365 (M1773_10370) 2213762..2214118 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T243996 WP_003410001.1 NZ_CP096847:c2209433-2208873 [Mycobacterium tuberculosis variant bovis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT243996 WP_003410003.1 NZ_CP096847:c2209771-2209430 [Mycobacterium tuberculosis variant bovis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAE4

References