243961

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3766538..3767223 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag M1775_RS17690 Protein ID WP_003417998.1
Coordinates 3766813..3767223 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M1775_RS17685 Protein ID WP_003912220.1
Coordinates 3766538..3766816 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS17665 (M1775_17660) 3762527..3764128 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
M1775_RS17670 (M1775_17665) 3764145..3764849 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
M1775_RS17675 (M1775_17670) 3764967..3765533 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
M1775_RS17680 (M1775_17675) 3765595..3766482 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
M1775_RS17685 (M1775_17680) 3766538..3766816 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M1775_RS17690 (M1775_17685) 3766813..3767223 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
M1775_RS17695 (M1775_17690) 3767256..3768992 - 1737 WP_003418002.1 cholesterol oxidase -
M1775_RS17700 (M1775_17695) 3769048..3770175 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
M1775_RS17705 (M1775_17700) 3770195..3771784 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T243961 WP_003417998.1 NZ_CP096846:3766813-3767223 [Mycobacterium tuberculosis variant bovis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT243961 WP_003912220.1 NZ_CP096846:3766538-3766816 [Mycobacterium tuberculosis variant bovis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References