243960

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3739334..3740001 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag M1775_RS17565 Protein ID WP_003417916.1
Coordinates 3739334..3739726 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag M1775_RS17570 Protein ID WP_003912214.1
Coordinates 3739726..3740001 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS17550 (M1775_17545) 3734704..3736542 - 1839 WP_023349617.1 1-deoxy-D-xylulose-5-phosphate synthase -
M1775_RS17555 (M1775_17550) 3736539..3737528 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
M1775_RS17560 (M1775_17555) 3737528..3738580 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
M1775_RS17565 (M1775_17560) 3739334..3739726 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
M1775_RS17570 (M1775_17565) 3739726..3740001 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M1775_RS17575 (M1775_17570) 3740183..3741554 + 1372 Protein_3471 ISNCY family transposase -
M1775_RS17580 (M1775_17575) 3741744..3743993 + 2250 WP_273585980.1 PE family protein -
M1775_RS17585 (M1775_17580) 3744064..3744936 - 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3740877..3741554 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T243960 WP_003417916.1 NZ_CP096846:c3739726-3739334 [Mycobacterium tuberculosis variant bovis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT243960 WP_003912214.1 NZ_CP096846:c3740001-3739726 [Mycobacterium tuberculosis variant bovis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References