243959

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3712212..3712741 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag M1775_RS17445 Protein ID WP_003417760.1
Coordinates 3712484..3712741 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag M1775_RS17440 Protein ID WP_003417757.1
Coordinates 3712212..3712487 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS17405 (M1775_17400) 3708785..3709474 - 690 WP_003917774.1 BBE domain-containing protein -
M1775_RS17410 (M1775_17405) 3709661..3710032 - 372 WP_003417739.1 FAD-binding protein -
M1775_RS17415 (M1775_17410) 3709930..3710148 - 219 WP_157132559.1 hypothetical protein -
M1775_RS17420 (M1775_17415) 3710175..3710435 - 261 WP_003417741.1 hypothetical protein -
M1775_RS17425 (M1775_17420) 3710550..3710939 + 390 WP_010950876.1 DUF732 domain-containing protein -
M1775_RS17430 (M1775_17425) 3710953..3711246 - 294 WP_003417749.1 DUF3017 domain-containing protein -
M1775_RS17435 (M1775_17430) 3711243..3712088 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
M1775_RS17440 (M1775_17435) 3712212..3712487 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
M1775_RS17445 (M1775_17440) 3712484..3712741 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
M1775_RS17450 (M1775_17445) 3712783..3713973 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
M1775_RS17455 (M1775_17450) 3714090..3714458 + 369 WP_003417765.1 FHA domain-containing protein -
M1775_RS17460 (M1775_17455) 3714455..3715006 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
M1775_RS17465 (M1775_17460) 3715013..3715594 - 582 WP_003417769.1 ATP/GTP-binding protein -
M1775_RS17470 (M1775_17465) 3715575..3715943 - 369 WP_003417772.1 DUF742 domain-containing protein -
M1775_RS17475 (M1775_17470) 3715921..3716313 - 393 WP_011799344.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T243959 WP_003417760.1 NZ_CP096846:3712484-3712741 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT243959 WP_003417757.1 NZ_CP096846:3712212-3712487 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References