243958

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3651844..3652518 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag M1775_RS17230 Protein ID WP_003417282.1
Coordinates 3651844..3652272 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag M1775_RS17235 Protein ID WP_003417286.1
Coordinates 3652276..3652518 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS17205 (M1775_17200) 3647666..3648067 - 402 WP_003417264.1 cytidine deaminase -
M1775_RS17210 (M1775_17205) 3648304..3648642 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
M1775_RS17215 (M1775_17210) 3648639..3649073 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
M1775_RS17220 (M1775_17215) 3649202..3650974 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
M1775_RS17225 (M1775_17220) 3650974..3651765 + 792 WP_010950870.1 succinate dehydrogenase iron-sulfur subunit -
M1775_RS17230 (M1775_17225) 3651844..3652272 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
M1775_RS17235 (M1775_17230) 3652276..3652518 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
M1775_RS17240 (M1775_17235) 3652640..3653254 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
M1775_RS17245 (M1775_17240) 3653251..3653916 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
M1775_RS17250 (M1775_17245) 3653917..3654450 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
M1775_RS17255 (M1775_17250) 3654447..3654821 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
M1775_RS17260 (M1775_17255) 3654918..3655922 - 1005 WP_003914475.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T243958 WP_003417282.1 NZ_CP096846:c3652272-3651844 [Mycobacterium tuberculosis variant bovis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT243958 WP_003417286.1 NZ_CP096846:c3652518-3652276 [Mycobacterium tuberculosis variant bovis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References