243956

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3128844..3129531 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag M1775_RS14875 Protein ID WP_003414624.1
Coordinates 3129088..3129531 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag M1775_RS14870 Protein ID WP_003414620.1
Coordinates 3128844..3129101 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS14850 (M1775_14845) 3124164..3125018 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
M1775_RS14855 (M1775_14850) 3125074..3126237 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
M1775_RS14860 (M1775_14855) 3126254..3127468 - 1215 WP_003414610.1 zinc metalloprotease Rip -
M1775_RS14865 (M1775_14860) 3127476..3128717 - 1242 WP_273585964.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
M1775_RS14870 (M1775_14865) 3128844..3129101 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
M1775_RS14875 (M1775_14870) 3129088..3129531 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
M1775_RS14880 (M1775_14875) 3129611..3130273 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
M1775_RS14885 (M1775_14880) 3130369..3130560 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
M1775_RS14890 (M1775_14885) 3130892..3132640 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
M1775_RS14895 (M1775_14890) 3132736..3133317 + 582 WP_003414644.1 fasciclin domain-containing protein -
M1775_RS14900 (M1775_14895) 3133417..3133683 + 267 WP_031657293.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T243956 WP_003414624.1 NZ_CP096846:3129088-3129531 [Mycobacterium tuberculosis variant bovis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT243956 WP_003414620.1 NZ_CP096846:3128844-3129101 [Mycobacterium tuberculosis variant bovis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
AlphaFold DB G0TFH0

References