243955

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3123243..3123791 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag M1775_RS14845 Protein ID WP_003414602.1
Coordinates 3123528..3123791 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag M1775_RS14840 Protein ID WP_003414599.1
Coordinates 3123243..3123524 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS14815 (M1775_14810) 3118866..3119723 - 858 WP_003899513.1 type I methionyl aminopeptidase -
M1775_RS14820 (M1775_14815) 3119765..3120349 - 585 WP_010950792.1 DUF1707 domain-containing protein -
M1775_RS14825 (M1775_14820) 3120453..3120701 + 249 WP_003913411.1 antitoxin VapB23 -
M1775_RS14830 (M1775_14825) 3120698..3121078 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
M1775_RS14835 (M1775_14830) 3121160..3122971 - 1812 WP_003414596.1 penicillin-binding protein -
M1775_RS14840 (M1775_14835) 3123243..3123524 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
M1775_RS14845 (M1775_14840) 3123528..3123791 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1775_RS14850 (M1775_14845) 3124164..3125018 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
M1775_RS14855 (M1775_14850) 3125074..3126237 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
M1775_RS14860 (M1775_14855) 3126254..3127468 - 1215 WP_003414610.1 zinc metalloprotease Rip -
M1775_RS14865 (M1775_14860) 3127476..3128717 - 1242 WP_273585964.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T243955 WP_003414602.1 NZ_CP096846:3123528-3123791 [Mycobacterium tuberculosis variant bovis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT243955 WP_003414599.1 NZ_CP096846:3123243-3123524 [Mycobacterium tuberculosis variant bovis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWP8

References