243952

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3059626..3060196 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag M1775_RS14515 Protein ID WP_003414166.1
Coordinates 3059626..3059982 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag M1775_RS14520 Protein ID WP_003901465.1
Coordinates 3059966..3060196 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS14495 (M1775_14495) 3055078..3056766 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
M1775_RS14500 (M1775_14500) 3056770..3057096 - 327 WP_003414157.1 hypothetical protein -
M1775_RS14505 (M1775_14505) 3057269..3057856 + 588 WP_003914429.1 DUF3558 family protein -
M1775_RS14510 (M1775_14510) 3057875..3059524 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
M1775_RS14515 (M1775_14515) 3059626..3059982 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
M1775_RS14520 (M1775_14520) 3059966..3060196 - 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
M1775_RS14525 (M1775_14525) 3060239..3061282 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
M1775_RS14530 (M1775_14530) 3061281..3061748 + 468 WP_003414177.1 DUF1778 domain-containing protein -
M1775_RS14535 (M1775_14535) 3061924..3062178 - 255 WP_003917684.1 hypothetical protein -
M1775_RS14540 (M1775_14540) 3062340..3062531 + 192 WP_003414184.1 hypothetical protein -
M1775_RS14545 (M1775_14545) 3062748..3063008 + 261 Protein_2870 transposase -
M1775_RS14550 (M1775_14550) 3064118..3064375 + 258 WP_003899489.1 hypothetical protein -
M1775_RS14555 (M1775_14555) 3064480..3064791 + 312 WP_010950777.1 hypothetical protein -
M1775_RS14560 (M1775_14560) 3064813..3065049 - 237 Protein_2873 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T243952 WP_003414166.1 NZ_CP096846:c3059982-3059626 [Mycobacterium tuberculosis variant bovis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT243952 WP_003901465.1 NZ_CP096846:c3060196-3059966 [Mycobacterium tuberculosis variant bovis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References