243951

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3020043..3020730 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name vapC Uniprot ID G0TF65
Locus tag M1775_RS14295 Protein ID WP_003414064.1
Coordinates 3020335..3020730 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag M1775_RS14290 Protein ID WP_003414061.1
Coordinates 3020043..3020309 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS14265 (M1775_14260) 3015682..3016584 - 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -
M1775_RS14270 (M1775_14265) 3016653..3017405 - 753 WP_003899465.1 FAD-dependent thymidylate synthase -
M1775_RS14275 (M1775_14275) 3017649..3017924 - 276 WP_003414055.1 type I restriction endonuclease subunit S -
M1775_RS14280 (M1775_14280) 3017921..3019543 - 1623 WP_003414057.1 class I SAM-dependent DNA methyltransferase -
M1775_RS14285 (M1775_14285) 3019630..3020046 - 417 WP_273585961.1 type II toxin-antitoxin system toxin ribonuclease C21 -
M1775_RS14290 (M1775_14290) 3020043..3020309 - 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1775_RS14295 (M1775_14295) 3020335..3020730 - 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin Toxin
M1775_RS14300 (M1775_14300) 3020727..3020996 - 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
M1775_RS14305 (M1775_14305) 3021006..3022100 - 1095 WP_003414068.1 restriction endonuclease subunit S -
M1775_RS14310 (M1775_14310) 3022097..3022516 - 420 Protein_2823 winged helix-turn-helix domain-containing protein -
M1775_RS14315 (M1775_14315) 3022515..3022589 + 75 Protein_2824 hypothetical protein -
M1775_RS14320 (M1775_14320) 3022590..3023069 - 480 WP_273586093.1 dihydrofolate reductase -
M1775_RS14325 (M1775_14325) 3023140..3023940 - 801 WP_003911953.1 thymidylate synthase -
M1775_RS14330 (M1775_14330) 3024096..3024833 + 738 WP_011799288.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14340.04 Da        Isoelectric Point: 4.7145

>T243951 WP_003414064.1 NZ_CP096846:c3020730-3020335 [Mycobacterium tuberculosis variant bovis]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT

Download         Length: 396 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT243951 WP_003414061.1 NZ_CP096846:c3020309-3020043 [Mycobacterium tuberculosis variant bovis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TF65

Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References