243949

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2890413..2891127 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag M1775_RS13535 Protein ID WP_003413460.1
Coordinates 2890687..2891127 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag M1775_RS13530 Protein ID WP_003413456.1
Coordinates 2890413..2890700 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS13495 (M1775_13490) 2885835..2886080 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
M1775_RS13500 (M1775_13495) 2886077..2886481 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
M1775_RS13505 (M1775_13500) 2886698..2887318 + 621 WP_003413441.1 DUF4178 domain-containing protein -
M1775_RS13510 (M1775_13505) 2887329..2887823 + 495 WP_003413444.1 DUF2617 family protein -
M1775_RS13515 (M1775_13510) 2887820..2888251 + 432 WP_003413445.1 DUF4247 domain-containing protein -
M1775_RS13520 (M1775_13515) 2888276..2888734 + 459 WP_003413451.1 DUF350 domain-containing protein -
M1775_RS13525 (M1775_13520) 2888731..2890302 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
M1775_RS13530 (M1775_13525) 2890413..2890700 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
M1775_RS13535 (M1775_13530) 2890687..2891127 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
M1775_RS13540 (M1775_13535) 2891148..2891903 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
M1775_RS13545 (M1775_13540) 2892036..2892632 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
M1775_RS13550 (M1775_13545) 2892640..2893485 - 846 WP_010950749.1 acyl-CoA thioesterase II -
M1775_RS13555 (M1775_13550) 2893514..2894413 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
M1775_RS13560 (M1775_13555) 2894541..2895215 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T243949 WP_003413460.1 NZ_CP096846:2890687-2891127 [Mycobacterium tuberculosis variant bovis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT243949 WP_003413456.1 NZ_CP096846:2890413-2890700 [Mycobacterium tuberculosis variant bovis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References