243944

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2767789..2768441 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag M1775_RS12965 Protein ID WP_003412752.1
Coordinates 2768016..2768441 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag M1775_RS12960 Protein ID WP_003412749.1
Coordinates 2767789..2768010 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS12945 (M1775_12940) 2766029..2766235 - 207 WP_003899347.1 hypothetical protein -
M1775_RS12950 (M1775_12945) 2766371..2766994 + 624 WP_003900858.1 TIGR00725 family protein -
M1775_RS12955 (M1775_12950) 2766984..2767736 + 753 WP_003901416.1 hypothetical protein -
M1775_RS12960 (M1775_12955) 2767789..2768010 + 222 WP_003412749.1 antitoxin Antitoxin
M1775_RS12965 (M1775_12960) 2768016..2768441 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
M1775_RS12970 (M1775_12965) 2768464..2769645 - 1182 WP_010950729.1 dihydrolipoamide acetyltransferase family protein -
M1775_RS12975 (M1775_12970) 2769642..2770688 - 1047 WP_010950730.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
M1775_RS12980 (M1775_12975) 2770699..2771802 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
M1775_RS12985 (M1775_12980) 2772061..2772882 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
M1775_RS12990 (M1775_12985) 2772879..2773436 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T243944 WP_003412752.1 NZ_CP096846:2768016-2768441 [Mycobacterium tuberculosis variant bovis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT243944 WP_003412749.1 NZ_CP096846:2767789-2768010 [Mycobacterium tuberculosis variant bovis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References