243939

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2232491..2233117 Replicon chromosome
Accession NZ_CP096846
Organism Mycobacterium tuberculosis variant bovis strain Mb2377

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag M1775_RS10440 Protein ID WP_003410075.1
Coordinates 2232719..2233117 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M1775_RS10435 Protein ID WP_019283586.1
Coordinates 2232491..2232718 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1775_RS10425 (M1775_10430) 2230530..2230874 - 345 WP_003410065.1 ferredoxin family protein -
M1775_RS10430 (M1775_10435) 2231063..2232232 - 1170 WP_003899126.1 ATP-binding protein -
M1775_RS10435 (M1775_10440) 2232491..2232718 + 228 WP_019283586.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1775_RS10440 (M1775_10445) 2232719..2233117 + 399 WP_003410075.1 PIN domain nuclease Toxin
M1775_RS10445 (M1775_10450) 2233300..2233731 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
M1775_RS10450 (M1775_10455) 2233880..2234266 + 387 WP_003899128.1 DUF1398 domain-containing protein -
M1775_RS10455 (M1775_10460) 2234703..2234882 - 180 Protein_2066 hypothetical protein -
M1775_RS10460 (M1775_10465) 2234970..2236133 + 1164 WP_242302829.1 IS110 family transposase -
M1775_RS10465 (M1775_10470) 2236261..2237517 - 1257 WP_003410095.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T243939 WP_003410075.1 NZ_CP096846:2232719-2233117 [Mycobacterium tuberculosis variant bovis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8347.14 Da        Isoelectric Point: 4.0995

>AT243939 WP_019283586.1 NZ_CP096846:2232491-2232718 [Mycobacterium tuberculosis variant bovis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSDDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure

References